POLI Antibody, FITC conjugated - Cat. #: CSB-PA892157LC01HU

SKU: CSB-PA892157LC01HU

Size :50ug

Clone Number:

Aliases:DNA polymerase iota antibody; Eta 2 antibody; Eta2 antibody; POLI antibody; POLI_HUMAN antibody; Polymerase (DNA directed) iota antibody; RAD 30B antibody; RAD30 homolog B antibody; RAD30, S. cerevisiae, homolog of antibody; RAD30B antibody; RAD3OB antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q9UNA4

Immunogen:Recombinant Human DNA polymerase iota protein (458-711AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:

Background:Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunogobulin genes. Forms a Schiff base with 5\'-deoxyribose phosphate at abasic sites, but may not have lyase activity.

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:FITC

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:POLI

Research Areas:Epigenetics and Nuclear Signaling