PKN1 Monoclonal Antibody

SKU: BT-MCA2014

Size:100μL

Background:The protein encoded by this gene belongs to the protein kinase C superfamily. This kinase is activated by Rho family of small G proteins and may mediate the Rho-dependent signaling pathway. This kinase can be activated by phospholipids and by limited proteolysis. The 3-phosphoinositide dependent protein kinase-1 (PDPK1/PDK1) is reported to phosphorylate this kinase, which may mediate insulin signals to the actin cytoskeleton. The proteolytic activation of this kinase by caspase-3 or related proteases during apoptosis suggests its role in signal transduction related to apoptosis. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Research_area:Signal Transduction

Target_protein:PKN1

applications:IHC, ICC, FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:4H10B1

Host:Mouse

Isotype:Mouse IgG2b

Gene Symbol/ Name:PKN1

Immunogen:Purified recombinant fragment of human PKN1 (AA: 442-620) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide.

Concentration:

Molecular weight(Da):104kDa

UniProt accession:Q16512

Synonyms:DBK, PKN, PAK1, PRK1, PAK-1, PRKCL1, PKN-ALPHA

GeneID:5585