Piezo1 antibody , Cat. # FNab06435

SKU: FNab06435

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Pore-forming subunit of a mechanosensitive non-specific cation channel(PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling(PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation(PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology(By similarity).

Immunogen:family with sequence similarity 38, member A

Synonyms:FAM38A, KIAA0233

Observed MW:250kd

Uniprot ID:Q92508

Reactivity:Human, Mouse

Tested Application:ELISA, WB,IHC

Recommended dilution: WB: 1:200-1:1000; IHC: 1:50-1:500

Gene ID:9780

Research Area: