PIEZO1 Antibody - Cat. #: CSB-PA852881ESR1HU

SKU: CSB-PA852881ESR1HU

Size :50ul

Clone Number:

Aliases:DHS antibody; Fam38a antibody; Family with sequence similarity 38 member A antibody; KIAA0233 antibody; Membrane protein induced by beta-amyloid treatment antibody; Mib antibody; PIEZ1_HUMAN antibody; Piezo-type mechanosensitive ion channel component 1 antibody; PIEZO1 antibody; Protein FAM38A antibody; Protein FAM38B antibody; Protein PIEZO1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q92508

Immunogen:Recombinant Human Piezo-type mechanosensitive ion channel component 1 protein (2230-2420AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, IHC; Recommended dilution: IHC:1:20-1:200

Background:Pore-forming subunit of a mechanosensitive non-specific cation channel (PubMed:23479567, PubMed:23695678). Generates currents characterized by a linear current-voltage relationship that are sensitive to ruthenium red and gadolinium. Plays a key role in epithelial cell adhesion by maintaining integrin activation through R-Ras recruitment to the ER, most probably in its activated state, and subsequent stimulation of calpain signaling (PubMed:20016066). In the kidney, may contribute to the detection of intraluminal pressure changes and to urine flow sensing. Acts as shear-stress sensor that promotes endothelial cell organization and alignment in the direction of blood flow through calpain activation (PubMed:25119035). Plays a key role in blood vessel formation and vascular structure in both development and adult physiology (By similarity).

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen Affinity Purified

Conjugate:Non-conjugated

Buffer:PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PIEZO1

Research Areas:Tags & Cell Markers