Phospho-XIAP (Ser87) Antibody - Cat. #: CSB-PA548634

SKU: CSB-PA548634

Size :100ul

Clone Number:

Aliases:AP 13 antibody; API3 antibody; Apoptosis Inhibitor 3 antibody; Baculoviral IAP repeat containing 4 antibody; Baculoviral IAP Repeat Containing Protein 4 antibody; Baculoviral IAP repeat-containing protein 4 antibody; BIRC 4 antibody; BIRC4 antibody; E3 ubiquitin-protein ligase XIAP antibody; hIAP-3 antibody; hIAP3 antibody; HILP antibody; IAP 3 antibody; IAP like protein antibody; IAP-3 antibody; IAP-like protein antibody; IAP3 antibody; ILP 1 antibody; ILP antibody; ILP1 antibody; Inhibitor of apoptosis protein 3 antibody; Inhibitor of Apoptosis X Linked antibody; Mammalian IAP Homologue A antibody; MIHA antibody; X linked IAP antibody; X linked inhibitor of apoptosis antibody; X linked inhibitor of apoptosis E3 ubiquitin protein ligase antibody; X linked inhibitor of apoptosis protein antibody; X-linked IAP antibody; x-linked inhibitor of apopotosis proteins antibody; X-linked inhibitor of apoptosis protein antibody; Xiap antibody; XIAP_HUMAN antibody; XLP2 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P98170

Immunogen:Peptide sequence around phosphorylation site of serine87(K-V-S(p)-P-N) derived from Human XIAP .

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, copper homeostasis, mitogenic kinase signaling, cell proliferation, as well as cell invasion and metastasis. Acts as a direct caspase inhibitor. Directly bind to the active site pocket of CASP3 and CASP7 and obstructs substrate entry. Inactivates CASP9 by keeping it in a monomeric, inactive state.

Huang X, Wu Z, Mei Y, Wu M (2013)EMBO J 32, 2204-16. Bornhauser BC, et al. (2007) Blood 110, 2084-91.Dan HC, et al. (2004)J Biol Chem 279, 5405-12.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:XIAP

Research Areas:Cancer;Cell biology;Metabolism