Phospho-PGR (Ser400) Antibody - Cat. #: CSB-PA220125

SKU: CSB-PA220125

Size :100ul

Clone Number:

Aliases:NR3C3 antibody; Nuclear receptor subfamily 3 group C member 3 antibody; PGR antibody; PR antibody; PRA antibody; PRB antibody; PRGR_HUMAN antibody; Progesterone receptor antibody; Progestin receptor form A antibody; Progestin receptor form B antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P06401

Immunogen:Peptide sequence around phosphorylation site of serine 400 (A-R-S(p)-P-R) derived from Human Progesterone Receptor.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Progesterone receptors (PRs) are nuclear hormone receptors of the NR3C class, which also includes mineralocorticoid,glucocorticoid and androgen receptors. They exist as homodimers coupled to Hsp90 or HMGB proteins, which are shed upon activation. The major signaling pathway used by progesterone receptors is via direct DNA binding and transcriptional regulation of target genes. They can also signal by binding to other proteins, mainly with transcription factors such as NF-kappaB, AP-1 or STAT. Progesterone receptors are found in the female reproductive tract, mammary glands, brain and pituitary gland and receptor expression is induced by estrogen. Well established functions of progesterone receptors include ovulation, implantation, mammary gland development and maintenance of pregnancy. In addition,progesterone, signaling through the progesterone receptor, increases the ventilatory response of the respiratory centers to carbon dioxide and decreases arterial and alveolar PCO2 in the luteal phase of the menstrual cycle and during pregnancy. The human gene encoding the progesterone receptor has been localized to 11q22.

Hagan CR, Knutson TP, Lange CA (2013) Nucleic Acids Res 41, 8926-42
Wang S, et al. (2013) J Biol Chem 288, 26265-74
Wardell SE, Narayanan R, Weigel NL, Edwards DP (2010) Mol Endocrinol 24, 335-45

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PGR

Research Areas:Epigenetics and Nuclear Signaling?Neuroscience?Cancer;Signal transduction