Phospho-MEF2A (Ser408) Antibody - Cat. #: CSB-PA968646

SKU: CSB-PA968646

Size :100ul

Clone Number:

Aliases:ADCAD1 antibody; MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A) antibody; MEF2 antibody; MEF2A antibody; MEF2A_HUMAN antibody; Myocyte enhancer factor 2A antibody; Myocyte-specific enhancer factor 2A antibody; RSRFC4 antibody; RSRFC9 antibody; Serum response factor like protein 1 antibody; Serum response factor-like protein 1 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q02078

Immunogen:Peptide sequence around phosphorylation site of serine 408 (P-I-S(p)-P-P) derived from Human MEF2A.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, IHC; IHC:1:50-1:100

Background:The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are one class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain

Okamoto SI, et al. (2002) Proc Natl Acad Sci USA; 99(6): 3974-3979.
Quinn ZA, et al. (2001) Nucleic Acids Res; 29(3): 732-742.
Kato Y, et al. (2000) J Biol Chem. 275(24): 18534-18540.
De Angelis L, et al. (1998) Proc Natl Acad Sci USA; 95(21): 12358-12363.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:MEF2A

Research Areas:Epigenetics and Nuclear Signaling?Neuroscience;Cardiovascular