Phospho-ITGB3 (Tyr785) Antibody - Cat. #: CSB-PA065810

SKU: CSB-PA065810

Size :100ul

Clone Number:

Aliases:BDPLT16 antibody; BDPLT2 antibody; CD 61 antibody; CD61 antibody; CD61 antigen antibody; GP3A antibody; GPIIIa antibody; GT antibody; HPA 1 antibody; HPA 4 antibody; Integrin beta 3 (platelet glycoprotein IIIa antigen CD61) antibody; Integrin beta chain beta 3 antibody; Integrin beta-3 antibody; ITB3_HUMAN antibody; ITG B3 antibody; ITGB 3 antibody; ITGB3 antibody; NAIT antibody; platelet fibrinogen receptor antibody; Platelet fibrinogen receptor beta subunit antibody; Platelet fibrinogen receptor, beta subunit antibody; Platelet glycoprotein IIIa antibody; Platelet glycoprotein IIIa precursor antibody; Platelet membrane glycoprotein IIIa antibody; PTP antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P05106

Immunogen:Peptide sequence around phosphorylation site of tyrosine 785 (I-T-Y(p)-R-G) derived from Human Integrin b3.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:Integrin a-V/beta-3 is a receptor for cytotactin, fibronectin, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin, vitronectin and von Willebrand factor. Integrin a-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin. Integrins a-IIb/beta-3 and a-V/beta-3 recognize the sequence R-G-D in a wide array of ligands. Integrin a-IIb/beta-3 recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain. Following activation integrin a-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen. This step leads to rapid platelet aggregation which physically plugs ruptured endothelial surface. In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions.

Sujoy Bhattacharya, et al. (2006) Biochem J. August 1; 397(Pt 3): 437

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ITGB3

Research Areas:Cardiovascular;Immunology;Signal transduction