Phospho-FOXO4 (Thr451) Antibody - Cat. #: CSB-PA939536

SKU: CSB-PA939536

Size :100ul

Clone Number:

Aliases:AFX antibody; AFX1 antibody; Afxh antibody; ALL1-fused gene from X chromosome antibody; Fork head domain transcription factor AFX1 antibody; Forkhead box O4 antibody; Forkhead box protein O4 antibody; FOXO 4 antibody; Foxo4 antibody; FOXO4_HUMAN antibody; MGC117660 antibody; MGC120490 antibody; Mixed lineage leukemia; translocated to; 7 antibody; MLLT7 antibody; Myeloid/lymphoid or mixed lineage leukemia (trithorax homolog; Drosophila); translocated to; 7 antibody; Myeloid/lymphoid or mixed lineage leukemia; translocated to; 7 antibody; RGD1561201 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P98177

Immunogen:Peptide sequence around phosphorylation site of Threonine 451(L-G-T(p)-P-V) derived from Human FOXO4.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:Transcription factor involved in the regulation of the insulin signaling pathway. Binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. Down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes. Also involved in negative regulation of the cell cycle. Involved in increased proteasome activity in embryonic stem cells (ESCs) by activating expression of PSMD11 in ESCs, leading to enhanced assembly of the 26S proteasome, followed by higher proteasome activity.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:FOXO4

Research Areas:Epigenetics and Nuclear Signaling