Phospho-FGFR4 (Tyr642) Polyclonal Antibody

SKU: E-AB-21090

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Acetyl/Phospho/Methyl Antibodies

Abbreviation: FGFR-4 (phospho Tyr642)

Target Synonym: CD 334;CD334;CD334 antigen;fc13h 10;fc13h10;Fgfr 4;FGFR-4;Fgfr4;FGFR4;Fibroblast growth factor receptor 4;Hydroxyaryl protein kinase;JTK 2;JTK2;MGC20292;Protein tyrosine kinase;TKF;Tyrosine kinase related to fibroblast growth factor receptor;Tyrosylprotein kinase

Research Areas: Cancer;Cell Biology;Cardiovascular;Neuroscience;Signal Transduction;Stem Cells;Tags and Cell Markers

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse;Rat

Application: WB

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: P22455

Accession:

Background: The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. FGFR4 (Fibroblast Growth Factor Receptor 4) is a Protein Coding gene. Diseases associated with FGFR4 include Prostate Cancer and Neuroma. Among its related pathways are GPCR Pathway and RET signaling. GO annotations related to this gene include transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. An important paralog of this gene is FGFR3.

Concentration: 1 mg/mL

Immunogen: Synthesized peptide derived from human FGFR-4 around the phosphorylation site of Tyr642

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification method: Affinity purification

Dilution: WB 1:500-1:2000

Calculated MW: 88kDa

ObservedMW: 90kDa