Phospho-DDIT3 (Ser30) Antibody - Cat. #: CSB-PA799326

SKU: CSB-PA799326

Size :100ul

Clone Number:

Aliases:C/EBP homologous protein antibody; C/EBP Homology Protein antibody; C/EBP zeta antibody; C/EBP-homologous protein 10 antibody; C/EBP-homologous protein antibody; CCAAT/enhancer binding protein homologous protein antibody; CEBPZ antibody; CHOP 10 antibody; CHOP antibody; CHOP-10 antibody; CHOP10 antibody; DDIT 3 antibody; DDIT-3 antibody; Ddit3 antibody; DDIT3_HUMAN antibody; DNA Damage Inducible Transcript 3 antibody; DNA damage-inducible transcript 3 protein antibody; GADD 153 antibody; GADD153 antibody; Growth Arrest and DNA Damage Inducible Protein 153 antibody; Growth arrest and DNA damage inducible protein GADD153 antibody; Growth arrest and DNA damage-inducible protein GADD153 antibody; MGC4154 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P35638

Immunogen:Peptide sequence around phosphorylation site of serine30(V-L-S(p)-S-D) derived from Human CHOP .

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression of C/EBP regulated genes. Positively regulates the transcription of TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA, BCL2L11/BIM and ERO1L.

Ubeda M, Habener JF (2003) J Biol Chem 278, 40514-20

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:DDIT3

Research Areas:Epigenetics and Nuclear Signaling;Developmental biology;Metabolism;Stem cells