Phospho-Caldesmon (S759) Polyclonal Antibody

SKU: BT-PHS01084

Size:100μL

Background:CALD1 (caldesmon 1) encodes a calmodulin- and actin-binding protein that plays an essential role in the regulation of smooth muscle and nonmuscle contraction. The conserved domain of this protein possesses the binding activities to Ca(2+)-calmodulin, actin, tropomyosin, myosin, and phospholipids. This protein is a potent inhibitor of the actin-tropomyosin activated myosin MgATPase, and serves as a mediating factor for Ca(2+)-dependent inhibition of smooth muscle contraction. Alternative splicing of this gene results in multiple transcript variants encoding distinct isoforms.

Research_area:Signal Transduction; Cardiovascular

Target_protein:CALD1

applications:IHC-p, ELISA

Reactivity:Human, mouse, rat

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:Phospho-Caldesmon (S759) Antibody

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):high molecular weight (predominantly in smooth muscles) (120-150 KD) and a low molecular weight (60

UniProt accession:Human: Q05682; Rat: Q62736

Synonyms:CALD1; CAD; CDM; Caldesmon; CDM

GeneID:Human: 800; Rat: 25687