Phospho-ATM (Ser1981) Polyclonal Antibody

SKU: E-AB-21540

Size: 200μL

Storage: Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping: The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date: 12 months

Category ID_II: Primary Antibodies

Category ID_III: Acetyl/Phospho/Methyl Antibodies

Abbreviation: Atm (phospho Ser1981)

Target Synonym: A-T mutated;A-T mutated homolog;AT mutated;AT1;ATA;Ataxia telangiectasia mutated;Ataxia telangiectasia mutated gene;Ataxia telangiectasia mutated homolog (human);Ataxia telangiectasia mutated homolog;ATC;ATD;ATDC;ATE;ATM;ATM serine/threonine kinase;ATM;DKFZp781A0353;MGC74674;OTTHUMP00000232981;Serine protein kinase ATM;Serine-protein kinase ATM;Serine/threonine-protein kinase ATM;Tefu;TEL1;TEL1;telomere maintenance 1;homolog;TELO1;Telomere fusion protein

Research Areas: Cancer;Epigenetics and Nuclear Signaling

Conjugation: Unconjugated

Host: Rabbit

Species reactivity: Human;Mouse

Application: WB;IHC-p

Isotype: IgG

Clonality: Polyclonal

Clone NO.:

UNIProt ID: Q13315

Accession:

Background: The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

Concentration: 1 mg/mL

Immunogen: Synthesized peptide derived from human Atm around the phosphorylation site of Ser1981

Buffer: PBS with 0.02% sodium azide, 0.5% protective protein and 50% glycerol, pH7.4

Purification method: Affinity purification

Dilution: WB 1:500-1:2000;IHC 1:50-1:200

Calculated MW:

ObservedMW: 350kDa