Phospho-ABL1 (Tyr204) Antibody - Cat. #: CSB-PA984556

SKU: CSB-PA984556

Size :100ul

Clone Number:

Aliases:Abelson murine leukemia viral oncogene homolog 1 antibody; Abelson tyrosine protein kinase 1 antibody; Abl 1 antibody; ABL antibody; ABL proto oncogene 1 non receptor tyrosine kinase antibody; ABL1 antibody; ABL1_HUMAN antibody; bcr/abl antibody; bcr/c abl oncogene protein antibody; c ABL antibody; c abl oncogene 1 non receptor tyrosine kinase antibody; c abl oncogene 1 receptor tyrosine kinase antibody; c ABL1 antibody; JTK7 antibody; p150 antibody; Proto oncogene tyrosine protein kinase ABL1 antibody; Proto-oncogene c-Abl antibody; Tyrosine-protein kinase ABL1 antibody; v abl Abelson murine leukemia viral oncogene homolog 1 antibody; v abl antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P00519

Immunogen:Peptide sequence around phosphorylation site of tyrosine 204 (K-L-Y(p)-V-S) derived from Human c-Abl.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:1000

Background:

Non-receptor tyrosine-protein kinase that plays a role in many key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion, receptor endocytosis, autophagy, DNA damage response and apoptosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like WASF3 (involved in branch formation); ANXA1 (involved in membrane anchoring); DBN1, DBNL, CTTN, RAPH1 and ENAH (involved in signaling); or MAPT and PXN (microtubule-binding proteins).

Meyn MA, et al. (2006) J Biol Chem 281, 30907-16
Steen H, et al. (2003) Mol Cell Proteomics 2, 138-45
Salomon AR, et al. (2003) Proc Natl Acad Sci U S A 100, 443-8

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy usi

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:ABL1

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Signal transduction