PHF1 Antibody - Cat. #: CSB-PA063428

SKU: CSB-PA063428

Size :100ul

Clone Number:

Aliases:hPCl1 antibody; MTF2 L2 antibody; MTF2L 2 antibody; MTF2L2 antibody; PCL 1 antibody; PCL1 antibody; PHD finger protein 1 antibody; PHD finger protein1 antibody; PHF 1 antibody; PHF 2 antibody; Phf1 antibody; PHF1_HUMAN antibody; PHF2 antibody; Plc 1 antibody; Plc1 antibody; Polycomb like protein 1 antibody; Polycomb like protein1 antibody; Polycomb-like protein 1 antibody; Protein PHF1 antibody; T complex testis expressed 3 antibody; T complex testis expressed3 antibody; Tctex 3 antibody; Tctex3 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:O43189

Immunogen:Synthesized peptide derived from internal of Human PHF1.

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:Polycomb group (PcG) that specifically binds histone H3 trimethylated at 'Lys-36' (H3K36me3) and recruits the PRC2 complex. Involved in DNA damage response and is recruited at double-strand breaks (DSBs). Acts by binding to H3K36me3, a mark for transcriptional activation, and recruiting the PRC2 complex: it is however unclear whether recruitment of the PRC2 complex to H3K36me3 leads to enhance or inhibit H3K27me3 methylation mediated by the PRC2 complex. According to some reports, PRC2 recruitment by PHF1 promotes H3K27me3 and subsequent gene silencing by inducing spreading of PRC2 and H3K27me3 into H3K36me3 loci (and ). According to another report, PHF1 recruits the PRC2 complex at double-strand breaks (DSBs) and inhibits the activity of PRC2 (). Regulates p53/TP53 stability and prolonges its turnover: may act by specifically binding to a methylated from of p53/TP53.

Coulson M., Genomics 48:381-383(1998).
Mungall A.J., Nature 425:805-811(2003).
The MGC Project Team, Genome Re

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PHF1

Research Areas:Epigenetics and Nuclear Signaling