PDGFB Antibody - Cat. #: CSB-PA017709KA01HU

SKU: CSB-PA017709KA01HU

Size :100ul

Clone Number:

Aliases:Becaplermin antibody; c sis antibody; FLJ12858 antibody; Oncogene SIS antibody; PDGF 2 antibody; PDGF B chain antibody; PDGF Beta antibody; PDGF subunit B antibody; PDGF-2 antibody; PDGF2 antibody; Pdgfb antibody; PDGFB_HUMAN antibody; Platelet derived growth factor 2 antibody; Platelet derived growth factor B chain antibody; Platelet derived growth factor beta antibody; Platelet derived growth factor beta polypeptide (oncogene SIS) antibody; Platelet derived growth factor beta polypeptide (simian sarcoma viral (v sis) oncogene homolog) antibody; Platelet derived growth factor beta polypeptide antibody; Platelet-derived growth factor B chain antibody; Platelet-derived growth factor beta polypeptide antibody; Platelet-derived growth factor subunit B antibody; Proto-oncogene c-Sis antibody; Simian sarcoma viral (v sis) oncogene homolog antibody; SIS antibody; SSV antibody; v sis platelet derived growth factor beta polypeptide antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:P01127

Immunogen:Recombinant protein of Human PDGFB

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB, IHC; WB:1:500-1:2000, IHC:1:50-1:200

Background:PDGF-BB is a cystine-linked homodimer PDGF family member with key roles in development, cell proliferation, cell survival, and angiogenesis. PDGF-BB is expressed by vascular endothelium, megakaryocytes and Leydig cells. PDGF-BB targets pericytes, fibroblasts, monocytes and other cell types. PDGF induces fibroblast growth and migration and is a chemoattractant for monocytes and granulocytes. Precursor PDGF-BB is cleaved intracellularly to generate a form that contains a carboxy-terminal stretch that serves to retain PDGF-BB in the extracellular matrix. In a second cleavage event, the carboxy-terminal stretch is removed extracellularly to generate mature PDGF-BB. PDGF-BB binds to PDGFR? and induces receptor dimerization. Signaling is through the PI3K/Akt, JNK, and PLC? pathways. PDGF-BB may have a role in some cancer types.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Affinity purification

Conjugate:Non-conjugated

Buffer:Store at -20°C or -80°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PDGFB

Research Areas:Cancer?Cardiovascular;Developmental biology;Metabolism;Signal transduction