PDCD4 Antibody - Cat. #: CSB-PA442649

SKU: CSB-PA442649

Size :50ul

Clone Number:

Aliases:Death up-regulated gene protein antibody; Dug antibody; H731 antibody; Ma3 antibody; MGC33046 antibody; MGC33047 antibody; Neoplastic transformation inhibitor antibody; Neoplastic transformation inhibitor protein antibody; Nuclear antigen H731 antibody; Nuclear antigen H731 like antibody; Nuclear antigen H731 like protein antibody; Nuclear antigen H731-like antibody; PDCD 4 antibody; Pdcd4 antibody; PDCD4_HUMAN antibody; Programmed cell death 4 antibody; programmed cell death 4 (neoplastic transformation inhibitor) antibody; Programmed cell death protein 4 antibody; Protein 197/15a antibody; Protein MA-3 antibody; Tis antibody; Topoisomerase-inhibitor suppressed protein antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q53EL6

Immunogen:Fusion protein of Human PDCD4

Raised in:Rabbit

Species Reactivity:Human, Mouse, Rat

Tested Applications:ELISA, WB; ELISA:1:1000-1:5000, WB:1:200-1:1000

Background:This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antigen affinity purification

Conjugate:Non-conjugated

Buffer:-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:PDCD4

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology