PCNT rabbit pAb

SKU: ES11924

Size: 100μL

Source:Rabbit

Applications:IHC;IF

Reactivity:Human;Mouse

Dilution:IHC-p 1:50-300

Immunogen:Synthesized peptide derived from part region of human protein

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):366kD

Human_gene_id:5116

Human_swiss_prot_no:O95613

Subcellular_location:Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Centrosomal at all stages of the cell cycle. Remains associated with centrosomes following microtubule depolymerization. Colocalized with DISC1 at the centrosome.

Other_name:

Background:The protein encoded by this gene binds to calmodulin and is expressed in the centrosome. It is an integral component of the pericentriolar material (PCM). The protein contains a series of coiled-coil domains and a highly conserved PCM targeting motif called the PACT domain near its C-terminus. The protein interacts with the microtubule nucleation component gamma-tubulin and is likely important to normal functioning of the centrosomes, cytoskeleton, and cell-cycle progression. Mutations in this gene cause Seckel syndrome-4 and microcephalic osteodysplastic primordial dwarfism type II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015],