PAX5 Polyclonal Antibody

SKU: E-AB-12615

Size::120μL

Storage:Store at -20℃ Valid for 12 months. Avoid freeze / thaw cycles.

Shipping:The product is shipped with ice pack,upon receipt,store it immediately at the temperature recommended.

Exp date:12 months

Category ID_II:Primary Antibodies

Category ID_III:Polyclonal Antibodies

Abbreviation:PAX5

Target Synonym:B cell lineage specific activator;B cell lineage specific activator protein;B cell specific activator protein;B cell specific transcription factor;B-cell-specific transcription factor;BSAP;EBB-1;KLP;Paired box 5;Paired box gene 5 (B cell lineage specific activator protein);Paired box gene 5 (B cell lineage specific activator);Paired box gene 5;Paired box homeotic gene 5;Paired box protein Pax 5;Paired box protein Pax-5;Paired domain gene 5;PAX 5;PAX5;PAX5;Transcription factor PAX 5

Research Areas:Cancer;Epigenetics and Nuclear Signaling;Neuroscience

Conjugation:Unconjugated

Host:Rabbit

Species reactivity:Human;Mouse

Application:WB

Isotype:IgG

Clonality:Polyclonal

Clone NO.:

UNIProt ID:Q02548

Accession:

Background:This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.

Concentration:0.5 mg/mL

Immunogen:Synthetic peptide of human PAX5

Buffer:PBS with 0.05% sodium azide and 50% glycerol, PH7.4

Purification method:Affinity purification

Dilution:WB 1:500-1:2000

Calculated MW:42kDa

ObservedMW: