p52 S6 kinase rabbit pAb

SKU: ES5514

Size: 100μL

Source:Rabbit

Applications:WB;IF;ELISA

Reactivity:Human;Mouse

Dilution:Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Immunogen:The antiserum was produced against synthesized peptide derived from human RPS6KC1. AA range:231-280

Storage_stability:-20°C/1 year

Clonality:Polyclonal

Isotype:IgG

Concentration:1 mg/ml

Observed_band(KD):117kD

Human_gene_id:26750

Human_swiss_prot_no:Q96S38

Subcellular_location:Cytoplasm . Membrane . Early endosome .

Other_name:RPS6KC1; RPK118; Ribosomal protein S6 kinase delta-1; S6K-delta-1; 52 kDa ribosomal protein S6 kinase; Ribosomal S6 kinase-like protein with two PSK domains 118 kDa protein; SPHK1-binding protein

Background:catalytic activity:ATP + a protein = ADP + a phosphoprotein.,caution:Instead of Lys-820, Arg-820 is found at the binding site.,domain:The first protein kinase domain appears to be a pseudokinase domain as it does not contain the classical characteristics, such as the ATP-binding motif, ATP-binding site and active site.,function:May be involved in transmitting sphingosine-1 phosphate (SPP)-mediated signaling into the cell.,similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. S6 kinase subfamily.,similarity:Contains 1 MIT domain.,similarity:Contains 1 PX (phox homology) domain.,similarity:Contains 2 protein kinase domains.,subcellular location:Also found in some small dot-like or ring-shaped early endosome structures.,subunit:Interacts with SPHK1 and phosphatidylinositol 3-phosphate.,tissue specificity:Highly expressed in testis, skeletal muscle, brain, heart, placenta, kidney and liver and weakly expressed in thymus, small intestine, lung and colon.,