NOTCH2 Monoclonal Antibody

SKU: BT-MCA4363

Size:100μL

Background:This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cleaved in the trans-Golgi network, and presented on the cell surface as a heterodimer. This protein functions as a receptor for membrane bound ligands, and may play a role in vascular, renal and hepatic development. Two transcript variants encoding different isoforms have been found for this gene.

Research_area:Neuroscience

Target_protein:NOTCH2

applications:FCM

Reactivity:Human

Clonality:Monoclonal

Clone ID:4C5A8

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:NOTCH2

Immunogen:Purified recombinant fragment of human NOTCH2 (AA:extra 1391-1677) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):265.4kDa

UniProt accession:Q04721

Synonyms:hN2, AGS2, HJCYS

GeneID:4853