NFKB2 (Ab-872) Antibody - Cat. #: CSB-PA274947

SKU: CSB-PA274947

Size :100ul

Clone Number:

Aliases:CVID10 antibody; DNA binding factor KBF2 antibody; DNA-binding factor KBF2 antibody; H2TF1 antibody; Lymphocyte translocation chromosome 10 antibody; Lymphocyte translocation chromosome 10 protein antibody; Lyt 10 antibody; Lyt10 antibody; NF kB2 antibody; NFKB2 antibody; NFKB2_HUMAN antibody; Nuclear factor NF kappa B p100 subunit antibody; Nuclear factor NF kappa B p52 subunit antibody; Nuclear factor NF-kappa-B p52 subunit antibody; Nuclear factor of kappa light chain gene enhancer in B cells 2 antibody; Nuclear factor of kappa light polypeptide gene enhancer in B cells 2 antibody; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 antibody; Oncogene Lyt 10 antibody; Oncogene Lyt-10 antibody; p105 antibody; p49/p100 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q00653

Immunogen:Peptide sequence around aa.870~874 (S-Q-S-V-E) derived from Human NFkB-p100.

Raised in:Rabbit

Species Reactivity:Human, Mouse

Tested Applications:ELISA, WB, IHC, IF; WB:1:500-1:1000, IHC:1:50-1:200, IF:1:100-1:200

Background:

NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively.

Shin HM, et al. (2006) EMBO J; 25(1): 129-138.
Li Q, et al. (2005) Proc Natl Acad Sci USA; 102(35): 12425-12430.
Chen C, et al. (2000) Mol Cell Biol; 20(8): 2687-2695.

Clonality:Polyclonal

Isotype:IgG

Purification Method:Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.

Conjugate:Non-conjugated

Buffer:Supplied at 1.0mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NFKB2

Research Areas:Epigenetics and Nuclear Signaling;Cancer;Cell biology;Signal transduction