NFKB1 antibody , Cat. # FNab10143

SKU: FNab10143

Size:100ug

Purification:Protein A+G purification

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Mouse

Clonality:monoclonal

Clone ID:1G4

Isotype:IgG2a

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3 , -20? for 12 months (Avoid repeated freeze / thaw cycles.)

Background:This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappa-B (NFKB) protein complex. NFKB is a transcription regulator that is activated by various intra- and extra-cellular stimuli such as cytokines, oxidant-free radicals, ultraviolet irradiation, and bacterial or viral products. Activated NFKB translocates into the nucleus and stimulates the expression of genes involved in a wide variety of biological functions. Inappropriate activation of NFKB has been associated with a number of inflammatory diseases while persistent inhibition of NFKB leads to inappropriate immune cell development or delayed cell growth. Alternative splicing results in multiple transcript variants encoding different isoforms, at least one of which is proteolytically processed.

Immunogen:nuclear factor of kappa light polypeptide gene enhancer in B-cells 1

Synonyms:DKFZp686C01211, DNA binding factor KBF1, EBP 1, KBF1, NF kappa B, NFKB p105, NFKB p50, NFKB1, NFKB1,p105, NFKB1,p105,p50, p105, p50

Observed MW:105 kDa/50 kDa

Uniprot ID:P19838

Reactivity:Human

Tested Application:ELISA, WB, IF

Recommended dilution:WB: 1:500 - 1:3000; IF: 1:20 - 1:200

Gene ID:4790

Research Area:Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Immunology, Cancer, Developmental biology, Neuroscience