NEIL3 Antibody - Cat. #: CSB-PA065468

SKU: CSB-PA065468

Size :100ul

Clone Number:

Aliases:123 antibody; AI449477 antibody; BC034753 antibody; C85903 antibody; DNA glycosylase FPG2 antibody; DNA glycosylase hFPG2 antibody; DNA glycosylase/AP lyase Neil3 antibody; EC 3.2.2.- antibody; EC 4.2.99.18 antibody; Endonuclease 8-like 3 antibody; Endonuclease VIII-like 3 antibody; FGP2 antibody; FLJ10858 antibody; FPG2 antibody; hFPG2 antibody; hNEI3 antibody; MGC27861 antibody; MGC36916 antibody; Nei endonuclease VIII-like 3 (E. coli) antibody; nei endonuclease VIII-like 3 antibody; Nei like 3 (E. coli) antibody; Nei-like protein 3 antibody; NEI3 antibody; NEIL3 antibody; NEIL3_HUMAN antibody; OTTHUMP00000218810 antibody; RGD1310562 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q8TAT5

Immunogen:Synthesized peptide derived from internal of Human NEIL3.

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA, WB; WB:1:500-1:3000

Background:DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA. No activity on 8-oxoG detected. Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity. In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues. Seems to be an important facilitator of cell proliferation in certain populations, for example neural stem/progenitor cells and tumor cells, suggesting a role in replication-associated DNA repair.

Takao M., J. Biol. Chem. 277:42205-42213(2002).
Ota T., Nat. Genet. 36:40-45(2004).
The MGC Project Team, Genome Res. 14:2121-2127(2004).

Clonality:Polyclonal

Isotype:IgG

Purification Method:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Conjugate:Non-conjugated

Buffer:Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Form:liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NEIL3

Research Areas:Epigenetics and Nuclear Signaling