NEDD4L Rabbit Polyclonal Antibody

SKU: BT-AP11514

Size:100μL

Background:This gene encodes a member of the Nedd4 family of HECT domain E3 ubiquitin ligases. HECT domain E3 ubiquitin ligases transfer ubiquitin from E2 ubiquitin-conjugating enzymes to protein substrates| thus targeting specific proteins for lysosomal degradation. The encoded protein mediates the ubiquitination of multiple target substrates and plays a critical role in epithelial sodium transport by regulating the cell surface expression of the epithelial sodium channel| ENaC. Single nucleotide polymorphisms in this gene may be associated with essential hypertension. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Research_area:Cell biology; Epigenetics and nuclear signaling

Target_protein:NEDD4L

applications:WB

Reactivity:Human, Mouse

Clonality:Polyclonal

Clone ID:

Host:Rabbit

Isotype:IgG

Gene Symbol/ Name:NEDD4L

Immunogen:The antiserum was produced against synthesized peptide derived from human AMPK alpha around the phosphorylation site of Thr172. AA range:140-189

Storage:-20°C for 1 year

Purification:The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Formulation:Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.

Concentration:1 mg/ml

Molecular weight(Da):

UniProt accession:Human: Q96PU5; Mouse: Q8CFI0

Synonyms:NEDD4L; E3 ubiquitin-protein ligase NEDD4-like; EC 6.3.2.-; NEDD4.2; Nedd4-2

GeneID:Human: 23327; Mouse: 0