NEDD4L Antibody, HRP conjugated - Cat. #: CSB-PA850411LB01HU

SKU: CSB-PA850411LB01HU

Size :50ug

Clone Number:

Aliases:E3 ubiquitin protein ligase NEDD4 like protein antibody; E3 ubiquitin-protein ligase NEDD4-like antibody; KIAA0439 antibody; NED4L_HUMAN antibody; NEDD4 2 antibody; NEDD4 2c antibody; Nedd4-2 antibody; NEDD4-2a antibody; NEDD4.2 antibody; NEDD4b antibody; NEDD4L antibody; NEDD4La antibody; NEDD4Lb antibody; NEDD4Lc antibody; NEDD4Ld antibody; NEDD4Le antibody; NEDD4Lf antibody; NEDD4Lg antibody; NEDD4Lh antibody; NEDL3 antibody; Neural precursor cell expressed developmentally down regulated 4 like E3 ubiquitin protein ligase antibody; Neural precursor cell expressed; developmentally down regulated 4 like antibody; RSP5 antibody; Ubiquitin protein ligase Rsp5 antibody

Product Type:Polyclonal Antibody

Immunogen Species:Homo sapiens (Human)

UniProt ID:Q96PU5

Immunogen:Recombinant Human E3 ubiquitin-protein ligase NEDD4-like protein (289-494AA)

Raised in:Rabbit

Species Reactivity:Human

Tested Applications:ELISA

Background:E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, KCNH2, EAAT1 or CLC5 (PubMed:26363003). Promotes ubiquitination and degradation of SGK1 and TNK2. Ubiquitinates BRAT1 and this ubiquitination is enhanced in the presence of NDFIP1 (PubMed:25631046). Plays a role in dendrite formation by melanocytes (PubMed:23999003). Involved in the regulation of TOR signaling (PubMed:27694961).

Clonality:Polyclonal

Isotype:IgG

Purification Method:>95%, Protein G purified

Conjugate:HRP

Buffer:Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form:Liquid

Stroage:Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Names:NEDD4L

Research Areas:Epigenetics and Nuclear Signaling; Cell biology