MYLK Monoclonal Antibody

SKU: BT-MCA2886

Size:100μL

Background:This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts.

Research_area:Signal Transduction

Target_protein:MYLK

applications:WB, IHC, ICC, FCM

Reactivity:

Clonality:Monoclonal

Clone ID:7F2B11

Host:Mouse

Isotype:Mouse IgG1

Gene Symbol/ Name:MYLK

Immunogen:Purified recombinant fragment of human MYLK (AA:1375-1524) expressed in E. Coli.

Storage:4°C|-20°C for long term storage

Purification:

Formulation:Purified antibody in PBS with 0.05% sodium azide

Concentration:

Molecular weight(Da):210kDa

UniProt accession:Q15746

Synonyms:KRP, AAT7, MLCK, MLCK1, MMIHS, MYLK1, smMLCK, MLCK108, MLCK210, MSTP083

GeneID:4638