MYL2 antibody , Cat. # FNab05486

SKU: FNab05486

Size:100ug

Purification:Immunogen affinity purified

Form:liquid

Purity:?95% as determined by SDS-PAGE

Host:Rabbit

Clonality:polyclonal

Clone ID:

Isotype:IgG

Storage:PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20? for 12 months(Avoid repeated freeze / thaw cycles.)

Background:Contractile protein that plays a role in heart development and function(By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force(By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly(By similarity).

Immunogen:myosin, light chain 2, regulatory, cardiac, slow

Synonyms:MLC2

Observed MW:18-20 kDa

Uniprot ID:P10916

Reactivity:Human, Mouse, Rat

Tested Application:ELISA, IHC, WB

Recommended dilution:WB: 1:500-1:2000; IHC: 1:20-1:200

Gene ID:4633

Research Area:Neuroscience, Immunology, Cardiovascular