Mouse Tubulin polymerization-promoting protein,TPPP ELISA KIT

SKU: E1253Mo

Size:96 Tests-1 Kit

Background:Regulator of microtubule dynamics that plays a key role in myelination by promoting elongation of the myelin sheath (PubMed:31522887). Acts as a microtubule nucleation factor in oligodendrocytes: specifically localizes to the postsynaptic Golgi apparatus region, also named Golgi outpost, and promotes microtubule nucleation, an important step for elongation of the myelin sheath (PubMed:31522887). Required for both uniform polarized growth of distal microtubules as well as directing the branching of proximal processes (PubMed:31522887). Shows magnesium-dependent GTPase activity; the role of the GTPase activity is unclear (By similarity). In addition to microtubule nucleation activity, also involved in microtubule bundling and stabilization of existing microtubules, thereby maintaining the integrity of the microtubule network (PubMed:18028908). Regulates microtubule dynamics by promoting tubulin acetylation: acts by inhibiting the tubulin deacetylase activity of HDAC6 (By similarity). Also regulates cell migration: phosphorylation by ROCK1 inhibits interaction with HDAC6, resulting in decreased acetylation of tubulin and increased cell motility (By similarity). Plays a role in cell proliferation by regulating the G1/S-phase transition (By similarity). Involved in astral microtubule organization and mitotic spindle orientation during early stage of mitosis; this process is regulated by phosphorylation by LIMK2 (By similarity). {ECO:0000250|UniProtKB:O94811, ECO:0000269|PubMed:18028908, ECO:0000269|PubMed:31522887}.

Research_area:

Applications:ELISA

Target_protein:Tppp

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.08ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Tubulin polymerization-promoting protein

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q7TQD2

MASS(Da):23575

GeneID:72948

Synonyms:Tppp

Gene names:Tppp

Standard solution:24ng/ml