Mouse tRNA pseudouridine synthase Pus10,PUS10 ELISA KIT

SKU: E1079Mo

Size:96 Tests-1 Kit

Background:Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm. In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs. tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs. In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity. Binds pri-miRNAs. Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage. Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death. {ECO:0000250|UniProtKB:Q3MIT2}.

Research_area:

Applications:ELISA

Target_protein:Pus10

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Putative tRNA pseudouridine synthase Pus10

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q9D3U0

MASS(Da):59710

GeneID:74467

Synonyms:Pus10 Ccdc139

Gene names:Pus10

Standard solution:24ng/ml