Mouse TNFRSF18/GITR ELISA Kit PicoKine®

SKU: EK0769

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: TNFRSF18

Specificity: Natural and recombinant mouse TNFRSF18

Background: Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. This gene is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.

Immunogen: Expression system for standard: NS0; Immunogen sequence: S22-H153

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Reference:

Uniprot ID: O35714

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 21936

Protein Name: Tumor necrosis factor receptor superfamily member 18

Gene Full Name: tumor necrosis factor receptor superfamily, member 18

Synonyms: TNF receptor superfamily member 18; AITR; CD357; ENERGEN; GITR; GITR-D; Tnfrsf18