Mouse T-cell Surface Glycoprotein Cd3 Epsilon Chain, CD3E ELISA Kit

SKU: E2505Mo

Size:96 Tests-1 Kit

Background:Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR), TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D, CD3E, CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement, these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN, resulting in the activation of downstream signaling pathways. In addition of this role of signal transduction in T-cell activation, CD3E plays an essential role in correct T-cell development (PubMed:19956738, PubMed:24899501). Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region.

Research_area:Immunology; Stem Cells

Applications:ELISA

Target_protein:CD3E

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.146ng/mL

Detection range:0.3-90ng/mL

Sample type:Serum, plasma or other biological fluids

Full product name:T-cell surface glycoprotein CD3 epsilon chain

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P22646

MASS(Da):21,393

GeneID:12501

Synonyms:AI504783;CD antigen CD3e;CD3;CD3E;CD3epsilon;T3e;T-cell surface antigen T3/Leu-4 epsilon chain;T-cell surface glycoprotein CD3 epsilon chain

Gene names:Cd3e

Standard solution:96ng/mL