Mouse Sialidase-4,NEU4 ELISA KIT

SKU: E1180Mo

Size:96 Tests-1 Kit

Background:Exo-alpha-sialidase that catalyzes the hydrolytic cleavage of the terminal sialic acid (N-acetylneuraminic acid, Neu5Ac) of a glycan moiety in the catabolism of glycolipids, glycoproteins and oligosacharides. Efficiently hydrolyzes gangliosides including alpha-(2->3)-sialylated GD1a and GM3 and alpha-(2->8)-sialylated GD3 (PubMed:19506080, PubMed:22393058). Hydrolyzes poly-alpha-(2->8)-sialylated neural cell adhesion molecule NCAM1 likely at growth cones, suppressing neurite outgrowth in hippocampal neurons (PubMed:19506080, PubMed:22393058). May desialylate sialyl Lewis A and X antigens at the cell surface, down-regulating these glycan epitopes recognized by SELE/E selectin in the initiation of cell adhesion and extravasation (By similarity). Has sialidase activity toward mucin, fetuin and sialyllactose (PubMed:19506080, PubMed:22393058). {ECO:0000250|UniProtKB:Q8WWR8, ECO:0000269|PubMed:19506080, ECO:0000269|PubMed:22393058}.

Research_area:

Applications:ELISA

Target_protein:Neu4

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.1ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Sialidase-4

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8BZL1

MASS(Da):52426

GeneID:241159

Synonyms:Neu4

Gene names:Neu4

Standard solution:24ng/ml