Mouse RANK / CD265 PicoKine® Quick ELISA Kit

SKU: FEK0830

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: Tnfrsf11a

Specificity: Natural and recombinant mouse RANK

Background: Receptor Activator of Nuclear Factor kappa B (RANK), also known as TRANCE Receptor, is a type I membrane protein that is expressed on the surface of osteoclasts and is involved in their activation upon ligand binding. RANK is a recently described TNF receptor family member, and its ligand, RANKL, promote survival of dendritic cells and differentiation of osteoclasts. RANK contains 383 amino acids in its intracellular domain (residues 234-616), which contain three putative TRAF-binding domains (termed I, II, and III). RANK interacts with various TRAFs through distinct motifs and activates NF-kappaB via a novel TRAF6 interaction motif, which then activates NIK, thus leading to NF-kappaB activation, whereas RANK most likely activates JNK through a TRAF2-interacting region in RANK.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q30-P213

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Reference:

Uniprot ID: O35305

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 21934

Protein Name: Tumor necrosis factor receptor superfamily member 11A

Gene Full Name: tumor necrosis factor receptor superfamily, member 11a, NFKB activator

Synonyms: TNF receptor superfamily member 11a; CD265; FEO; LOH18CR1; ODFR; OFE; OPTB7; OSTS; PDB2; RANK; TRANCER; Tnfrsf11a