Mouse Protein Wnt-5A, WNT5AELISA Kit

SKU: E1496Mo

Size:96 Tests-1 Kit

Background:Ligand for members of the frizzled family of seven transmembrane receptors (PubMed: 17117926). Can activate or inhibit canonical Wnt signaling, depending on receptor context (PubMed: 16602827). In the presence of FZD4, activates beta-catenin signaling. In the presence of ROR2, inhibits the canonical Wnt pathway by promoting beta-catenin degradation through a GSK3-independent pathway which involves down-regulation of beta-catenin-induced reporter gene expression (PubMed: 16602827). Suppression of the canonical pathway allows chondrogenesis to occur and inhibits tumor formation. Stimulates cell migration (PubMed: 17117926). Decreases proliferation, migration, invasiveness and clonogenicity of carcinoma cells and may act as a tumor suppressor. Mediates motility of melanoma cells (By similarity). Required during embryogenesis for extension of the primary anterior-posterior axis and for outgrowth of limbs and the genital tubercle (PubMed: 10021340). Inhibits type II collagen expression in chondrocytes (By similarity).

Research_area:Stem Cells

Applications:ELISA

Target_protein:WNT5A

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.021ng/ml

Detection range:0.05-20ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Protein Wnt-5A

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P22725

MASS(Da):42,309

GeneID:22418

Synonyms:Protein Wnt-5a;WNT 5A;WNT5A

Gene names:WNT5A

Standard solution:25.6ng/ml