Mouse Protein S100-A4, S100A4 ELISA Kit

SKU: E2394Mo

Size:96 Tests-1 Kit

Background:Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy (PubMed: 20519440). Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9 (PubMed: 8051043). Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis (PubMed: 8051043). Modulates also the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels (By similarity). Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes (PubMed: 20103644). In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors (By similarity).

Research_area:Signal Transduction

Applications:ELISA

Target_protein:S100A4

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:14.16ng/L

Detection range:30-9000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Protein S100-A4

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P07091

MASS(Da):11,721

GeneID:20198

Synonyms:Metastasin;Metastatic cell protein;PEL98;Placental calcium-binding protein;Protein 18A2;Protein Mts1;Protein S100-A4;S100 calcium-binding protein A4;S100A4;

Gene names:S100A4

Standard solution:9600ng/L