Mouse Phosphate-regulating neutral endopeptidase PHEX,PHEX ELISA KIT

SKU: E2754Mo

Size:96 Tests-1 Kit

Background:Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity (By similarity). Cleaves ASARM peptides between Ser and Glu or Asp residues (By similarity). Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide (PubMed:11159866, PubMed:18597632, PubMed:26051469). Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides (PubMed:26051469). Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation (By similarity). {ECO:0000250|UniProtKB:P78562, ECO:0000269|PubMed:11159866, ECO:0000269|PubMed:26051469, ECO:0000305|PubMed:18597632}.

Research_area:

Applications:ELISA

Target_protein:Phex

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.11ng/ml

Detection range:0.25-16ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:P70669

MASS(Da):86419

GeneID:18675

Synonyms:Phex Hyp Pex

Gene names:Phex

Standard solution:32ng/ml