Mouse PECAM-1/CD31/PECAM1 PicoKine® Quick ELISA Kit

SKU: FEK0874

Size: 96 wells/kit, with removable strips.

Storage: Store at 4°C for 6 months. (Ships with gel ice, can store for up to 3 days in room temperature. Refrigerate upon receipt.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: Pecam1

Specificity: Natural and recombinant Mouse Pecam1

Background: PECAM-1 is an important target GP in DITP.1 Platelet/endothelial cell adhesion molecule-1(PECAM-1) is a 130-kD member of the Ig gene superfamily that is expressed on the surface of circulating platelets, monocytes, neutrophils, and selective T-cell subsets.2 Platelet endothelial cell adhesion molecule-1(PECAM-1/CD31) is a member of the immunoglobulin(Ig) superfamily that has distinctive features of an immunoreceptor based upon its genomic structure and the presence of intrinsic immunoreceptor tyrosine inhibitory motifs(ITIMs) in its ligand binding polypeptide.3 PECAM-1 has recently been shown to contain functional immunoreceptor tyrosine-based inhibitory motifs(ITIMs) within its cytoplasmic domain, and co-ligation of PECAM-1 with the T-cell antigen receptor(TCR) results in tyrosine phosphorylation of PECAM-1, recruitment of Src homology 2 domain-containing protein tyrosine phosphatase-2(SHP-2), and attenuation of TCR-mediated cellular signaling.4 The standard used in this kit is the product of gene recombinant expression(extracellular part), consisting of 563 amino acids(E28-K590) with the molecular weight of 65.5KDa. After glycosylating, its molecular weight changes to 91-100KDa.

Immunogen: Expression system for standard: NS0; Immunogen sequence: E18-K590

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Uniprot ID: Q08481

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 18613

Protein Name: Platelet endothelial cell adhesion molecule

Gene Full Name: platelet/endothelial cell adhesion molecule 1

Synonyms: CD31; EndoCAM; GPIIA; PECA1; PECAM 1; PECAM1; VEC marker