Mouse NGFR/TNFRSF16 ELISA Kit PicoKine®

SKU: EK2126

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: Ngfr

Specificity: Natural and recombinant mouse Ngfr

Background: Nerve growth factor receptor (NGFR) is also referred to as p75(NTR) because of its ability to bind at low affinity not only to NGF, but also other neurotrophins including brain-derived neurotrophic factor (BDNF), neurotrophin-3 and neurotrophin-4/5. The nerve growth factor receptor gene is at human chromosome region 17q12-17q22, distal to the chromosome 17 breakpoint in acute leukemias. The neurotrophin receptor p75(NTR), a tumor necrosis factor receptor superfamily member expressed in hepatic stellate cells after fibrotic and cirrhotic liver injury in humans, is a regulator of liver repair. In mice, depletion of p75(NTR) exacerbated liver pathology and inhibited hepatocyte proliferation in vivo. In addition, it is showed that neurotrophins activate p75(NTR) to induce apoptosis through the induction of the sphingomyelin (SM) cycle and increased production of ceramide. Overexpression of p75(NTR) is also found to activate the SM pathway.

Immunogen: Expression system for standard: NS0; Immunogen sequence: K22-P246

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Uniprot ID: Q9Z0W1

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 18053

Protein Name: Tumor necrosis factor receptor superfamily member 16

Gene Full Name: nerve growth factor receptor (TNFR superfamily, member 16)

Synonyms: CD271; Gp80 LNGFR; NGF receptor; NGFR; p75; p75 ICD; p75(NTR); p75NTR; TNFRSF16