Mouse Neurogenic locus notch homolog protein 2,NOTCH2 ELISA KIT

SKU: E1393Mo

Size:96 Tests-1 Kit

Background:Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination (PubMed:10393120). Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:10393120, PubMed:18710934). Affects the implementation of differentiation, proliferation and apoptotic programs (PubMed:10393120, PubMed:18710934). May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation (By similarity). In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:18710934). Positively regulates self-renewal of liver cancer cells (By similarity). {ECO:0000250|UniProtKB:Q04721, ECO:0000269|PubMed:10393120, ECO:0000269|PubMed:18710934}.

Research_area:

Applications:ELISA

Target_protein:Notch2

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.08ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Neurogenic locus notch homolog protein 2

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O35516

MASS(Da):265633

GeneID:18129

Synonyms:Notch2

Gene names:Notch2

Standard solution:24ng/ml