Mouse Nad-dependent Protein Deacetylase Sirtuin-3, SIRT3 ELISA Kit

SKU: E2586Mo

Size:96 Tests-1 Kit

Background:NAD-dependent protein deacetylase (PubMed: 23835326, PubMed: 17923681, PubMed: 18794531, PubMed: 21172655, PubMed: 26620563). Activates or deactivates mitochondrial target proteins by deacetylating key lysine residues (PubMed: 23835326, PubMed: 17923681, PubMed: 18794531, PubMed: 21172655). Known targets include ACSS1, IDH, GDH, PDHA1, SOD2, LCAD, SDHA and the ATP Synthase subunit ATP5PO (PubMed: 16790548, PubMed: 18794531, PubMed: 21172655). Contributes to the regulation of the cellular energy metabolism (PubMed: 23835326). Important for regulating tissue-specific ATP levels (PubMed: 18794531, PubMed: 24252090). In response to metabolic stress, deacetylates transcription factor FOXO3 and recruits FOXO3 and mitochondrial RNA polymerase POLRMT to mtDNA to promote mtDNA transcription (PubMed: 23283301). Acts as a regulator of ceramide metabolism by mediating deacetylation of ceramide Synthases CERS1, CERS2 and CERS6, thereby increasing their activity and promoting mitochondrial ceramide accumulation (PubMed: 26620563).

Research_area:Others

Applications:ELISA

Target_protein:SIRT3

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.047ng/ml

Detection range:0.1-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Nad-Dependent Protein Deacetylase Sirtuin-3

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8R104

MASS(Da):36,615

GeneID:64384

Synonyms:mSIR2L3;NAD-dependent protein deacetylase sirtuin-3;Regulatory protein SIR2 homolog 3;SIR2-like protein 3;SIRT 3;SIRT3

Gene names:SIRT3

Standard solution:48ng/ml