Mouse N-Myc-Interactor, NMI ELISA Kit

SKU: E2311Mo

Size:96 Tests-1 Kit

Background:Acts as a signaling pathway regulator involved in innate immune system response (PubMed: 23956435). In response to interleukin 2/IL2 and interferon IFN-gamma/IFNG, interacts with signal transducer and activator of transcription/STAT which activate the transcription of downstream genes involved in a multitude of signals for development and homeostasis (By similarity). Enhances the recruitment of CBP/p300 coactivators to STAT1 and STAT5, resulting in increased STAT1- and STAT5-dependent transcription (By similarity). In response to interferon IFN-alpha, associates in a complex with transcriptional regulator IFI35 to regulate immune response; the complex formation prevents proteasome-mediated degradation of IFI35 (By similarity). In complex with IFI35, negatively regulates nuclear factor NF-kappa-B signaling by inhibiting the nuclear translocation, activation and transcription of NF-kappa-B subunit p65/RELA, resulting in the inhibition of endothelial cell proliferation, migration and re-endothelialization of injured arteries (By similarity). Negatively regulates virus-triggered type I interferon/IFN production by inducing proteosome-dependent degradation of IRF7, a transcriptional regulator of type I IFN, thereby interfering with cellular antiviral responses (PubMed: 23956435). Beside its role as an intracellular signaling pathway regulator, also functions extracellularly as damage-associated molecular patterns (DAMPs) to promote inflammation, when actively released by macrophage to the extracellular space during cell injury or pathogen invasion (By similarity). Macrophage-secreted NMI activates NF-kappa-B signaling in adjacent macrophages through Toll-like receptor 4/TLR4 binding and activation, thereby inducing NF-kappa-B translocation from the cytoplasm into the nucleus which promotes the release of proinflammatory cytokines (By similarity).

Research_area:Epigenetics and Nuclear Signaling

Applications:ELISA

Target_protein:NMI

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:5.19ng/L

Detection range:10-2000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:N-Myc-Interactor

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O35309

MASS(Da):35,236

GeneID:64685

Synonyms:NMI;N-myc and STAT interactor;N-myc-interactor

Gene names:NMI

Standard solution:2400ng/L