Mouse Mothers against decapentaplegic homolog 7,Smad7 ELISA KIT

SKU: E0468Mo

Size:96 Tests-1 Kit

Background:Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit TGF-beta (Transforming growth factor) and activin signaling by associating with their receptors thus preventing SMAD2 access. Functions as an adapter to recruit SMURF2 to the TGF-beta receptor complex. Also acts by recruiting the PPP1R15A-PP1 complex to TGFBR1, which promotes its dephosphorylation. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. {ECO:0000250|UniProtKB:O15105}.

Research_area:

Applications:ELISA

Target_protein:Smad7

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.19ng/ml

Detection range:0.38-24ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Mothers against decapentaplegic homolog 7

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:O35253

MASS(Da):46442

GeneID:17131

Synonyms:Smad7 Madh7 Madh8

Gene names:Smad7

Standard solution:48ng/ml