Mouse Microphthalmia-associated transcription factor,Mitf ELISA KIT

SKU: E2801Mo

Size:96 Tests-1 Kit

Background:Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to M-boxes (5'-TCATGTG-3') and symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR) (PubMed:23207919). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium. {ECO:0000250|UniProtKB:O75030, ECO:0000269|PubMed:23207919}.

Research_area:

Applications:ELISA

Target_protein:Mitf

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.27ng/ml

Detection range:0.63-40ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q08874

MASS(Da):58605

GeneID:17342

Synonyms:Mitf Bw Mi Vit

Gene names:Mitf

Standard solution:80ng/ml