Mouse Meteorin-like/METRNL ELISA Kit PicoKine®

SKU: EK1550

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: Metrnl

Specificity: Natural and recombinant mouse Meteorin-like

Background: METRNL (Meteorin-like) is a cytoplasmic 30 kDa (predicted) member of the meteorin family of proteins. It is expressed by neurons, and appears to function as a primer molecule that sets the stage for either cell differentiation or neurite outgrowth when it acts with Dclk1 and SerpinB1. In mice, exogenously elevated circulating Metrnl increased whole-body energy expenditure and improved glucose tolerance following diet-induced obesity. It also induced expression of antiinflammatory genes, leading to alternative activation of macrophages in adipose tissue and to browning of white fat depots. Metrnl did not appear to activate thermogenic genes ly, but it stimulated eosinophils and macrophages to enter adipose tissue and take their specific thermogenic actions. Blockade of cytokine signaling eliminated Metrnl-induced changes in gene expression required for alternative macrophage activation and blunted expression of beige fat thermogenic and beta-oxidation genes. It is concluded that METRNL is a hormone that influences energy expenditure and thermogenic programs in adipose tissue.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q46-E311

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Reference:

Uniprot ID: Q8VE43

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 210029

Protein Name: Meteorin-like protein

Gene Full Name: meteorin, glial cell differentiation regulator-like

Synonyms: Meteorin-like protein; Metrnl; Subfatin, METRNL