Mouse Interleukin-1 Receptor Accessory Protein, IL1RAP ELISA Kit

SKU: E2172Mo

Size:96 Tests-1 Kit

Background:Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD (PubMed: 25908590). May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells (By similarity). [Isoform 2]: Associates with secreted ligand-bound IL1R2 and increases the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Enhances the ability of secreted IL1R1 to inhibit IL-33 signaling. [Isoform 3]: Required for Src phosphorylation by IL1B. Required for IL1B-potentiated NMDA-induced calcium influx in neurons acting in cooperation with IL1R1 isoform 2 to mediate Akt kinase activation.

Research_area:Immunology

Applications:ELISA

Target_protein:IL1RAP

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:23.84ng/L

Detection range:50-10000ng/L

Sample type:Serum, plasma or other biological fluids

Full product name:Interleukin-1 Receptor Accessory Protein

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q61730

MASS(Da):65,741

GeneID:16180

Synonyms:IL 1RAP;IL-1 receptor accessory protein;IL-1RAcP;IL1RAP;Interleukin-1 receptor accessory protein;Interleukin-33 receptot beta chain

Gene names:IL1RAP

Standard solution:12800ng/L