Mouse IL-24/Interleukin-24 ELISA Kit PicoKine®

SKU: EK1359

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: Il24

Specificity: Natural and recombinant mouse IL-24

Background: Interleukin 24 (IL-24) is a cytokine belonging to the IL-10 family of cytokines that signals through two heterodimeric receptors: IL-20R1/IL-20R2 and IL-22R1/IL-20R2. This interleukin is also known as Melanoma differentiation-associated 7 (mda-7) due to its discovery as a tumour suppressing protein. By radiation hybrid analysis, the MDA7 gene is mapped to 1q32.2-q41. IL-24 appears to control in cell survival and proliferation by inducing rapid activation of particular transcription factors called Stat-1 and Stat-3. Mouse IL24 was expressed as an approximately 35-kD protein that was converted to a 23-kD protein by deglycosylation. The IL24 protein shares 24 to 33% homology with other members of the IL10 family of cytokines, with highest homology with IL20. This cytokine is predominantly released by activated monocytes, macrophages and T helper 2 (Th2) cells and acts on non-haematopoietic tissues such as skin, lung and reproductive tissues. IL-24 performs important roles in wound healing, psoriasis and cancer.

Immunogen: Expression system for standard: E.coli; Immunogen sequence: Q27-L181

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Uniprot ID: Q925S4

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 93672

Protein Name: Interleukin-24

Gene Full Name: interleukin 24

Synonyms: C49A; FISP; IL 24; IL10B; IL24; IL-24; interleukin 24; mda 7; MDA7; Mob 5; ST16