Mouse Hemojuvelin/RGM-C/HJV ELISA Kit PicoKine®

SKU: EK1370

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: HFE2

Specificity: Natural and recombinant mouse Hemojuvelin

Background: Hemojuvelin (HJV/RGMc/HFE2) is a membrane-bound and soluble protein in mammals. It is a member of a three gene family (in vertebrates) called the repulsive guidance molecules. In mouse, the Hemojuvelin protein is encoded by the HFE2 gene, and it is mapped to Chromosome 3. It was concluded that downregulation of hepatic Hemojuvelin during inflammation may induce a temporary elimination of iron sensing. Hemojuvelin is a coreceptor for bone morphogenetic proteins (BMPs), and inhibition of endogenous BMP signaling reduces hepcidin expression and increases serum iron in mice. Furthermore, Hemojuvelin may play inhibitory roles in prostate cancer by suppressing cell growth, adhesion, migration and invasion.

Immunogen: Expression system for standard: NS0; Immunogen sequence: Q33-D393

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Reference:

Uniprot ID: Q7TQ32

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 69585

Protein Name: Hemojuvelin

Gene Full Name: hemojuvelin BMP co-receptor

Synonyms: Hemochromatosis type 2 protein; Hemojuvelin; HFE2; HFE2A; HJV; JH; RGM domain family member C; RGMC