Mouse Gliomedin,GLDN ELISA KIT

SKU: E0874Mo

Size:96 Tests-1 Kit

Background:Ligand for NRCAM and NFASC/neurofascin that plays a role in the formation and maintenance of the nodes of Ranvier on myelinated axons. Mediates interaction between Schwann cell microvilli and axons via its interactions with NRCAM and NFASC (PubMed:20188654). Nodes of Ranvier contain clustered sodium channels that are crucial for the saltatory propagation of action potentials along myelinated axons. During development, nodes of Ranvier are formed by the fusion of two heminodes. Required for normal clustering of sodium channels at heminodes; not required for the formation of mature nodes with normal sodium channel clusters (PubMed:20188654). Required, together with NRCAM, for maintaining NFASC and sodium channel clusters at mature nodes of Ranvier (PubMed:24719088). {ECO:0000250|UniProtKB:Q80WL1, ECO:0000269|PubMed:20188654, ECO:0000269|PubMed:24719088}.

Research_area:

Applications:ELISA

Target_protein:Gldn

Reactivity:Mouse

Assay type:Sandwich

Sensitivity:0.09ng/ml

Detection range:0.19-12ng/ml

Sample type:Serum, plasma or other biological fluids

Full product name:Gliomedin

Species:Mouse

Storage:2-8ºC

Assay time:1h 30m

UniProt accession:Q8BMF8

MASS(Da):59137

GeneID:235379

Synonyms:Gldn Crgl2

Gene names:Gldn

Standard solution:24ng/ml