Mouse GFRA1 ELISA Kit PicoKine®

SKU: EK2070

Size: 96 wells/kit, with removable strips.

Storage: Store at 4℃ for 6 months, at -20℃ for 12 months. Avoid multiple freeze-thaw cycles (Ships with gel ice, can store for up to 3 days in room temperature. Freeze upon receiving.)

Form:

Reactivity: Mouse

Applications: ELISA

Application Details:

Gene Name: Gfra1

Specificity: Natural and recombinant mouse GFRA1

Background: GDNF family receptor alpha-1 (GFRα1), also known as the GDNF receptor, is a protein that in humans is encoded by the GFRA1 gene. It is mapped to 19 D2; 19 54.18 cM. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Two alternatively spliced transcript variants encoding different isoforms have been described for this gene.GDNF family receptor alpha 1 has been shown to interact with GDNF and RET proto-oncogene.

Immunogen: Expression system for standard: NS0; Immunogen sequence: D25-S430

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Uniprot ID: P97785

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Cross Reactivity: There is no detectable cross-reactivity with other relevant proteins.

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Gene ID: 14585

Protein Name: GDNF family receptor alpha-1

Gene Full Name: glial cell line derived neurotrophic factor family receptor alpha 1

Synonyms: Golgi-associated; gamma adaptin ear-containing; ARF-binding protein 1; Gga1; Gfra1